NOT KNOWN FACTUAL STATEMENTS ABOUT NR1-SITE

Working with this strategy, Kalbaugh et al. assigned affinity and efficacy roles to positions from the LBDs of your NR1 and NR2A NMDAR subunits. In situ mutation of residues in direct contact with certain ligand affected each efficacy and affinity, although positions that stabilize the shut cleft conformation with out a immediate ligand interaction